About 10 years ago, Levent Keskintepe PhD and I introduced Comparative Genomic Hybridization (CGH) into the clinical IVF arena, as a preimplantation genetic sampling (PGS) method that enables full karyotyping (numerically chromosomal analysis) of all 23 pairs of an embryo’s … Read more
The potential for a woman’s eggs to undergo orderly development and maturation, while in large part being genetically determined can be profoundly influenced by the woman’s age, her “ovarian reserve” and proximity to menopause. It is also influenced by the … Read more
Thrombophilia (Hereditary Clotting Defect) is defined as the genetic predisposition to developing intravascular thrombosis. It is due to hypercoagulability of blood leading to impairment of initial vascularization that takes place during implantation.
Thrombophilia affects as many as one in five … Read more
Ovarian reserve is the term used to describe the extent of a woman’s ovarian egg supply. Diminished ovarian reserve (DOR) refers to a reduction in the total number of eggs left in the ovaries such that resistance builds to ovarian … Read more
In order for any organism to attain an optimal state of maturation (ripening) it must first undergo full growth and development. A fruit plucked from a tree before having developed fully or a poorly developed fruit might still ripen (mature) … Read more
Patrick Steptoe and Robert Edwards were responsible for the birth of the world’s 1st IVF baby, Louise Brown, in 1978. Since then about 4 million babies have been born worldwide, and the number is growing fast. The introduction of … Read more
As a woman ages beyond 30 years, the quality of her eggs starts to decline progressively and with it also her fertility potential. By age 40 she is about half as likely to conceive and by her mid forties she … Read more
Hi Dr Sher,
I am considering pursuing egg freezing in a few months. I had an initial consult with and RE in which my numbers were as follows:
Age: 34 years, 8 months
Day 3 FSH: 8.1MIU/ml
Day 3 AMH: … Read more
An ever increasing number of American women first seek IVF treatment in their late 30’s or early 40’s.This trend is in large part due to the fact that more and more women are choosing to defer childbearing until they have … Read more
Endometriosis is a condition that occurs when the uterine lining (endometrium) grows not only in the interior of the uterus but in other areas, such as the Fallopian tubes, ovaries and the bowel. Endometriosis is a complex condition where, the … Read more
Sher-IVF Success Rate
IVF SUCCESS RATE EXPRESSED AS VIABLE PREGNANCY RATE PER EMBRYO TRANSFERRED (PRPE): A PROPOSED NEW PRADIGM FOR IMPROVED AND VERIFIABLE REPORTING OF IVF STATISTICS
Genetically Testing IVF Embryos
A Case for Transferring Blastocysts on Day 5-6 Post-Fertilization Rather Than on Day 2-3 as Cleaved Embryos.
Management of Immunologic Implantation Dysfunction (IID)
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