When confronted with “unexplained” IVF failures where morphologically good embryos were transferred, the question arises as to whether the problem is due to inherent egg/embryo “incompetence” (which usually equates with an irregular chromosomal configuration [aneuploidy]) or whether it is due … Read more

Whenever IVF fails to resolve reproductive failure, the explanation is almost invariably either:  a) embryo “incompetence” (usually …although not always due to the embryo being karyotypically abnormal or aneuploid) or b) implantation dysfunction (anatomical/ immunologic). So…should the transfer of  up … Read more

About 10 years ago, Levent Keskintepe PhD and I introduced Comparative Genomic Hybridization (CGH) into the clinical IVF arena, as a preimplantation genetic sampling (PGS) method that enables full karyotyping (numerically chromosomal analysis) of  all 23 pairs of an embryo’s … Read more

The potential for a woman’s eggs to undergo orderly development and maturation, while in large part being genetically determined can be profoundly influenced by the woman’s age, her “ovarian reserve” and proximity to menopause. It is also influenced by the … Read more