Over the past three decades, I have met and consulted with tens of thousands of couples seeking treatment for diverse reproductive issues involving infertility and pregnancy loss. The universal thread that I have encountered is people’s hunger for information when … Read more
When confronted with “unexplained” IVF failures where morphologically good embryos were transferred, the question arises as to whether the problem is due to inherent egg/embryo “incompetence” (which usually equates with an irregular chromosomal configuration [aneuploidy]) or whether it is due … Read more
The bottom line is that because of the traumatic effect of freezing on egg viability and “competency” the statistical chance of each frozen/ thawed egg ultimately resulting in a baby is only at best 6-8%. So, while success rates following … Read more
Whenever IVF fails to resolve reproductive failure, the explanation is almost invariably either: a) embryo “incompetence” (usually …although not always due to the embryo being karyotypically abnormal or aneuploid) or b) implantation dysfunction (anatomical/ immunologic). So…should the transfer of up … Read more
About 10 years ago, Levent Keskintepe PhD and I introduced Comparative Genomic Hybridization (CGH) into the clinical IVF arena, as a preimplantation genetic sampling (PGS) method that enables full karyotyping (numerically chromosomal analysis) of all 23 pairs of an embryo’s … Read more
The potential for a woman’s eggs to undergo orderly development and maturation, while in large part being genetically determined can be profoundly influenced by the woman’s age, her “ovarian reserve” and proximity to menopause. It is also influenced by the … Read more
Thrombophilia (Hereditary Clotting Defect) is defined as the genetic predisposition to developing intravascular thrombosis. It is due to hypercoagulability of blood leading to impairment of initial vascularization that takes place during implantation.
Thrombophilia affects as many as one in five … Read more
Ovarian reserve is the term used to describe the extent of a woman’s ovarian egg supply. Diminished ovarian reserve (DOR) refers to a reduction in the total number of eggs left in the ovaries such that resistance builds to ovarian … Read more
In order for any organism to attain an optimal state of maturation (ripening) it must first undergo full growth and development. A fruit plucked from a tree before having developed fully or a poorly developed fruit might still ripen (mature) … Read more
Patrick Steptoe and Robert Edwards were responsible for the birth of the world’s 1st IVF baby, Louise Brown, in 1978. Since then about 4 million babies have been born worldwide, and the number is growing fast. The introduction of … Read more
The Role of IVF in the Management of Infertility Caused by Pelvic Inflammation
Hormonal Supplementation in IVF
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