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Dr. Sher Blog
Official Blog of Dr. Geoffrey Sher
Ovarian Hyperstimulation Syndrome (OHS): Its Evolution & Reducing its Incumbent Risks.
Ovarian hyperstimulation syndrome (OHS) is a condition where a woman receiving fertility drugs (usually gonadotropins) over-responds by developing a large number of ovarian follicles which upon administration of hCG, “triggers” a series of systemic events that can place the woman’s … Read more
Sher-IVF Success Rate
Given rapidly changing practices in the IVF arena, it is becoming increasingly implausible to reliably interpret current national reports expressing IVF outcome statistics as birth rate per initiated treatment cycle, per egg retrieval procedure or per embryo transfer procedure performed…AND … Read more
IVF SUCCESS RATE EXPRESSED AS VIABLE PREGNANCY RATE PER EMBRYO TRANSFERRED (PRPE): A PROPOSED NEW PRADIGM FOR IMPROVED AND VERIFIABLE REPORTING OF IVF STATISTICS
Given rapidly changing practices in the IVF arena, it is becoming increasingly implausible to reliably interpret current national reports expressing IVF outcome statistics as birth rate per initiated treatment cycle, per egg retrieval procedure or per embryo transfer procedure performed. … Read more
Genetically Testing IVF Embryos
Preimplantation genetic screening (PGS) involves testing pre-implantation embryos for chromosomal numerical abnormalities (aneuploidy). Preimplantation genetic diagnosis (PGD) involves genetic testing of embryos for specific genetic conditions. The objective of both PGS and PGD is to identify embryos that are aneuploid … Read more
Management of Immunologic Implantation Dysfunction (IID)
In the United States, effective treatment of NK/CTL activation associated with either alloimmune or autoimmune implantation dysfunction requires the administration of primarily Intralipid (IL). Such treatment is much more likely to be successful in the case of` autoimmune implantation dysfunction … Read more
Genetically Testing Embryos for IVF
Preimplantation Genetic Screening (PGS): PGS is the process whereby the chromosomes in the cells of an embryo (or the polar body of an egg) are examined (karyotyped). Embryo cells that have all 46 chromosomes intact are termed euploid. Those with … Read more
Management of Immunologic Implantation Dysfunction (IID)
In the United States, effective treatment of natural killer cell /cytotoxic lymphocyte (NK/CTL)-activation associated with either alloimmune or autoimmune implantation dysfunction requires the administration of primarily Intralipid (IL) or Intravenous gamma-globulin (IVIg). Such treatment is much more likely to be … Read more
Does Frozen Embryo Transfer (FET) Improve IVF Success?
“I am in full agreement with researchers at Cambridge University in the United Kingdom who following a recent published a report on their observation that FET enhances IVF outcome, stated that this could represent one of the most “exciting” IVF … Read more
Performing Embryo Transfer: The “Process”
Embryo transfer (ET) is undoubtedly a rate limiting factor in IVF. Unquestionably, the IVF doctor’s expertise in performing ET as one of the most important factors that will determine IVF outcome. It takes confidence, dexterity, skill, gentility and above all, … Read more
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