For many women, disease, the physiological decline in ovarian reserve (DOR) and spontaneous or pathologically induced menopause will preclude pregnancy using own eggs. For such women, the performance of IVF using the eggs of a chosen young third party (egg … Read more
Dr. Sher Blog
Official Blog of Dr. Geoffrey Sher
Recurrent Pregnancy Loss (RPL): Why do I keep losing my Pregnancies and What can be Done?
When it comes to reproduction, humans are the poorest performers of all mammals. In fact we are so inefficient that up to 75% of fertilized eggs do not produce live births, and up to 30% of pregnancies end up being … Read more
Secondary Infertility: Addressing the Root Causes
It is one thing for a woman who has never been able to conceive (primary infertility) to come to grips with undergoing In Vitro Fertilization. It is quite another matter for someone who has successfully achieved a pregnancy in the … Read more
Staggered IVF: An Excellent Option When Advancing Age and Diminished Ovarian Reserve (DOR) Reduces IVF Success Rate
Many physicians treating infertile women over 40 years old who have patent fallopian tubes still opt to start with the least invasive strategy rather than going straight to IVF. This usually begins with the prescribing of oral and then injectable … Read more
The Role of Nutritional Supplements in Preparing for IVF
It is important to nurture and take care of yourself mentally and physically when preparing and going through your IVF journey. This starts with trying to have a positive attitude about what you are about to go through, creating a … Read more
Thyroid autoantibodies and Immunologic Implantation Dysfunction (IID)
Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with reproductive failure i.e. infertility, unexplained (often repeated) IVF failure, or recurrent pregnancy loss (RPL). The condition is 5-10 … Read more
Preventing Severe Ovarian Hyperstimulation Syndrome with “Prolonged Coasting”
I do not use antagonists in high responders (e.g., PCOS) because it interferes with the assay of E2 (often causing the value to be understated), a valuable index in assessing risk for the development of severe/critical OHSS. I also do … Read more
Understanding Polycystic Ovarian Syndrome (PCOS) and the Need to Customize Ovarian Stimulation Protocols
Polycystic ovary syndrome (PCOS) is a common hormonal system disorder among women affecting between 5% and 10% of women of reproductive age worldwide. Women with PCOS may have enlarged ovaries that contain small collections of fluid — called follicles — … Read more
Immunologic Implantation Dysfunction (IID) & Infertility (IID): PART 1-Background
In 15-20% of women who have infertility or RPL, the cause will be immunologic implantation dysfunction (IID). Accordingly, all women who have predisposing factors such as endometriosis, unexplained infertility/repeated failed IVF, RPL, or have a personal/family history of primary autoimmune … Read more
Implications of “Empty Follicle Syndrome and “Premature Luteinization”
Frequently, when following vigorous and often repeated flushing of follicles at egg retrieval they fail to yield eggs, it is ascribed to “Empty Follicle Syndrome.” This is a gross misnomer, because all follicles contain eggs. So why were no eggs … Read more
Recent Posts
- Case Report: The Diagnosis of “Unexplained” Recurrent IVF-Failure is Sometimes a Cop-out
- Case Report: IVF in a 32y old with Premature-Menopause Following Cancer Chemotherapy.
- Case Report: Intractable Damage to the Uterine Lining (Asherman Syndrome ) causing Failed Implantation
Selecting the Ideal Protocol for Controlled Ovarian Stimulation!- Case Report: Endometrios Causing IVF Failures due to Embryo Implantation Dysfunction (IID)
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